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| CUNICO,MIRIAM M.; TREBIEN,HERBERT A.; GALETTI,FÁBIO C.; MIGUEL,OBDULIO G.; MIGUEL,MARILIS D.; AUER,CELSO G.; SILVA,CÉLIO L.; SOUZA,ANA OLÍVIA DE. |
| ABSTRACT Ottonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Analgesic; Anesthetic; Antimycobacterial; Ottonia martiana; Piperaceae; Piperovatine. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000501991 |
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